Proceedings

Day 3 - Thursday, September 28, 2000

ThOA

Is LC/TOF a Viable Bioanalytical Tool?

While quadrupole based LC-MS/(MS) systems dominate the quantitative bioanalytical arena, orthogonal time-of-flight (TOF) detection capable of fast acquisition rates and accurate mass discrimination offer features which when coupled with HPLC, make it an attractive bioanalytical tool. This session highlighted both the merits and current limitations of LC-TOF (or Q-TOF) when utilized for bioanalysis.

LC/TOF for GLP

LC/TOF for Discovery

High Throughput Protein Identification by Mass Spectrometry

Roundtable Discussion 10

ThOB

Data Management and Manipulation

There has been a revolution in chemistry as combichem techniques and technologies have become broadly adopted by synthetic chemistry groups, especially in the pharmaceutical industry. The challenge of providing structural support for orders of magnitude increases in samples has created a number of issues related to data acquisition, data management, data interpretation, and data storage. This session explored some of these issues and approaches to meeting these challenges.

Spectroscopy Management and Prediction Tools for the Screening of Combinatorial Library Analytical Data

Information Solutions for High Throughput LC/MS Purity and Structure Determination in Drug Discovery

Roundtable Discussion 11

ThOC

Drugability High Throughput Screening: In Vitro Methods

Screening and Analytical Measurements of the Relative Hydrophobicity and Lipophilicity of Chemical Compounds for Drug Discovery

High-Throughput Measurements of Lipophilicity for Lead Optimization Using RP-HPLC

High-Throughput Screening Method for Measurement of the Phospholipid Membrane Permeability, Aqueous Solubility and Membrane Retention of Molecules

LC/MS-Based LogP Method

High-Throughput Stability Assessments

High-Throughput pKa

Roundtable Discussion 12

ThOD:

New Technologies and Future Trends for High Throughput

The world is changing around high throughput analysis. LC/MS and related technologies had their prime time in 1990's. They have revolutionized the way we perform pharmaceutical analysis. In this session, we looked at new ways to improve our efficiency and productivity in analytical laboratories. "Lab-on-a-chip" is certainly starting to show its potential in drug discovery and it will bring us another revolution in the near future. In the meantime, scientists are thinking creatively and figuring out new ways to improve LC/MS productivity using various new hardware and software. Automation in every aspect of LC/MS bioanalysis will change our laboratories dramatically.

Miniaturized, Integrated and Automated Pharmaceutical Discovery Experimentation With Lab-on-a-Chip Systems

Caught in a Parallel World: Stretching the Boundaries of Bioanalytical Mass Spectrometry

Roundtable Discussion 13