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CPSA 2004

Integrated Approaches to Drug Discovery & Development:
Turning Measurements to Medicine
October 18 - 21, 2004

CPSA Digest 2004

Day 1: Proceedings | Plenary
Day 2: Proceedings
Day 3: Proceedings

CPSA 2004 Sponsors

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CPSA Digest 2004


Proceedings

Day 1 - Monday, September 22, 2003



Overview

Objectives/Format/Opening Remarks

Program Chair:Nigel J. Clarke, ActivX Biosciences


Plenary

The Multi-Dimensionality of the Proteome

Simon J. Gaskell, The University of Manchester Institute of Science and Technology


Functional Proteomics I: Quantitation

 Discussion Leader: Jonathan Burbaum, ActivX Biosciences

Interactive Panel Discussion:
Leo E. Bonilla, Thermo Electron
John A. Chakel, Agilent Technologies
Ashok Dongre, Bristol-Myers Squibb
Patrick R. Griffin, ExSAR Corporation
Roy Martin, Waters
Todd Pihl, Celera Genomics


Roundtable Discussion

Discovery and Validation of Proteomic Biomarkers for Drug Development

Discussion Leader: Mike S. Lee, Milestone Development Services
  • Analytical Methodologies for Protein Discovery
  • 1-D or 2-D LC/LC Fractionation
  • MUDPIT and Shotgun Methods
  • Affinity Protein Chips
  • Protein Arrays
  • Current and Future Challenges
  • Detection and Sensitivity
  • Validation: in-vitro/in-vivo models
  • Clinical Relevance


Functional Proteomics II: Relationships

 Discussion Leader: Patrick R. Griffin, ExSAR Corporation

Identification and Classification of Protein-Ligand Interaction Modes by Hydrogen/Deuterium Exchange by Mass Spectrometry

Yoshi Hamuro, ExSAR Corporation

Evaluation of Protein and Drug Interactions with Serum Albumin

Ellen Rohde, Merck Research Laboratories

Mechanistic Analysis of Lipophilic Glycopeptide Antibiotics Using Affinity Chromatography

Ranabir Sinha Roy, Merck Research Laboratories

Roundtable Discussion



Bioinformatics for Proteomics

 Discussion Leader: John A. Chakel, Agilent Technologies

Quantitation of Differentially Expressed Proteins

Terri Addona, Millennium Pharmaceuticals

Database Searching with Mass Spectrometry-Derived Data

Akhilesh Pandey, Johns Hopkins University

Chemical Strategies for Proteome Analysis

Bradford Gibson, Buck Institute

A High-Throughput Pipeline for the Analysis of MS/MS Data

Mark S. Friedrichs, Bristol-Myers Squibb

Roundtable Discussion



Vendor/Exhibitor Session:
Proteomics Technologies & Applications

 Discussion Leader: Brian Williamson, Applied Biosystems

An Overview of NanoLC and Sample Preparation Strategies for Mass Spectrometry in the Field of Proteomics

Jeffrey W. Finch, Waters Corporation

High Throughput SDS-Protein Separations by Multiplexed Capillary Gel Electrophoresis with UV Absorption Detection

Siquan Luo, Jianmin Feng, Ho-ming Pang, and Dennis Tallman, CombiSep, Inc.

Proteome Analysis of Human Plasma with the ProteomeLab(tm) PF-2D System

Stephen Wagner, Beckman-Coulter, Inc.

Increased Throughput and Separation in Nano-HPLC-MS Using a Dual-Gradient Nano-HPLC System and Monolithic Columns

Remco van Soest, LC Packings/Dionex

Reproducible Removal Of Multiple High-Abundant Proteins From Human Serum With Polyclonal Antibody-Based LC Affinity Column

Kelly Zhang, Agilent Technologies

Proteomics Technologies & Applications

Luke Roenneburg, Gilson, Inc.

Microfluidic HPLC System for Highly Sensitive Peptide Identification by LC-MS

Jeff Jensen, Eksigent Technologies

Atmospheric Pressure MALDI Update

Brian Musselman, SciMarket Strategies

Variable Flow Gradient LC-MS: Spray Mode Signal Affects and Control

Gary A. Valaskovic, New Objective, Inc.

The Sensitivity Increase with IONICS EP 10+ System

Dragan Vuckovic, IONICS Mass Spectrometry Group, Inc.

Improved Bottom-Up Protein Identification Using A New Two-Dimensional Ion Trap Mass Spectrometer

Leo E Bonilla, ThermoFinnigan Corporation

Protein Expression Profiling: Current Trends and Future Horizons

Roy Martin, Waters Corporation, Beverly, MA, USA.

A New Way to Think About 2D Gel and LC/MS/MS Experiments: The New 4700 Proteomics Discovery System

Dale H. Patterson, Applied Biosystems

High Resolution Biomarker Discovery Solutions for Clinical Proteomics

Mark T. Flocco, Bruker Daltonics, Inc.

A Flexible Asset Management Program for Proteomics Instrument Acquisition

Paul Corcoran, McKinley Scientific

Contracting LC/MS for Biomolecules - Can We Do It? Yes We Can!

Kathleen Anderson, Novatia


Poster Sessions

Chairs: Alex Buko, Biogen and David S. Wagner, GlaxoSmithKline
  1. Protein Identification
  2. Marker Discovery
  3. New Targets
  4. Eprogen versus MUDPIT versus Shotgun
  5. High Throughput Analysis



Content © 2003
Milestone Development Services.
All rights reserved.

Design© 2003
Royal Station
All rights reserved.
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