CPSA Digest 2003

Day 1

Vendor Session - Proteomics Technologies & Applications

Atmospheric Pressure MALDI Update

The capability to complete Matrix Assisted Laser Desorption experiments with samples at atmospheric pressure was commercialized only a few years ago. Since that time improvements in the technology have been made including methods to ionize samples directly from liquid matrices, and with improved sensitivity owing to modulation of the electrostatic field during the ionization process. This presentation will document the development of the AP/MALDI-Pulse Dynamic Focusing for improved sensitivity and the AP/IRIS for Infared-based ionization from solutions. Results of analysis with these sources as completed on conventional LC/MS instruments will be described.

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