CPSA Digest 2003

Day 1

Vendor Session - Proteomics Technologies & Applications

A New Way to Think About 2D Gel and LC/MS/MS Experiments:
The New 4700 Proteomics Discovery System

The task of identifying, quantifying and characterizing the proteins that play key roles in biological function requires analysis tools that support the multiple sample workflows dictated by the complexity of proteomics samples as well as sophisticated bioinformatics tools to turn these protein identifications into biological answers. The new 4700 Proteomics Discovery System is tailored as the definitive solution for analyzing proteins from gel-based and MDLC experiments. In addition, it is the first platform to provide a direct link from the protein identifications to the wealth of information and bioinformatic tools in the Celera Discovery System (CDS). The 4700 Proteomics Discovery System is defined by the revolutionary 4700 Proteomics Analyzer with TOF/TOF' Optics running the new v2.0 software, DeNovo Explorer with ProBLAST, and v2.0 of GPS Explorer' Software containing integrated links to the biological information in CDS. The MALDI ionization process employed has the distinct advantage of having the samples "frozen" on the plate, which enables decoupling of the MS from the MS/MS as well as further data acquisition post result analysis. The v2.0 software takes full aim at this feature by enabling multiple result-dependent experiments including Peptide Mass Fingerprinting confirmation, Peptide Mass Fingerprinting Low Confidence Investigation and ICAT Expression-Dependent Analysis. In addition, it is the first commercially available software to fully support LC-MALDI experiments with its unique LC precursor selection algorithm and Peak Explorer software for viewing the mass chromatograms. This system and its unique advantages will be presented by showing the results from 2D gel and MDLC proteomics workflows.

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