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Day 2
Vendor Session - Drug Discovery Technologies & Applications
High Throughput Applications of Multiplexed Capillary Electrophoresis
with Absorbance Detection in Drug Discovery and Development
Jeremy Kenseth, Andrea Bastin, and Dennis Tallman
CombiSep, Inc.
The emergence of combinatorial synthesis and high throughput activity
screening methods have prompted the need for the development of
supporting high throughput analytical approaches for characterizing
various physical and chemical properties of active lead compounds.
Experimental information acquired regarding drug physicochemical
properties such as acid dissociation constants (pKa values) and
octanol-water partition coefficients (log P values) can identify active
compounds that also possess favorable "drug-like" properties. This
approach can help reduce attrition rates and increase overall success in
drug development. This presentation will discuss the use of
multiplexed, absorbance-based capillary electrophoresis (CE) for
determining pKa values and log P values in a high throughput manner. In
addition, the use of multiplexed CE for performing parallel chiral
separations will be presented. The ability to rapidly screen compounds
for various properties in parallel offers a substantial scientific and
business advantage as compared to the use of traditional, lower
throughput serial-based approaches.
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