CPSA Digest 2003

Day 2

Vendor Session - Drug Discovery Technologies & Applications

Sustained Carryover Elimination in LC/MS Drug Analysis

Many new drug formulations consist of extremely basic and hydrophobic compounds. These compounds can be problematic due to their tendency to absorb to the sampling pathway of typical HPLC autosamplers. Normal rinse procedures are unable to reduce the resulting cross contamination. This poster provides data obtained from an LC/MS autosampler that utilizes an innovative rinse procedure that virtually eliminates carryover. The analyte data from Quetiapine, Bis[2-(2-[4-(dibenzo[b,f][1,4]thiazepin-11-yl]ethoxy)ethanol] was obtained from a Sciex API 3000 in LC/MS/MS mode.

This blank directly following the high standard Chlorhexidine injection shows carryover to be 0.091%. The metal flow path (platinum needle and Hastelloy C valve) has contributed to the increased carryover for this sample.		This blank following two high standard injections has a carryover peak that is unable to be integrated since it is buried in the noise.

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