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Day 2
Vendor Session - Drug Discovery Technologies & Applications
A Practical Cryodetector Mass Spectrometer for High Sensitivity
Detection and Energy Resolution at High Mass
R.Chalk1, R.Seydoux1, L.Schultheis1, U.Matter1, and Brian Musselman2
1Comet Analytics AG; 2SciMarket Strategies
Conventional micro-channel plate (MCP) detectors work by ejection of
electrons following the impact of high velocity ions to initiate an
electron cascade. It follows that this process is much less efficient
for large, low velocity ions, and thus MCP detector efficiency decreases
exponentially with increasing mass. This fact can be readily observed
during the analysis of intact proteins, nucleic acids and polymers,
where the usefulness of mass spectrometry has so far been severely
limited above 10 kDa. Superconducting tunneling junction (STJ) detectors
have no such limitation however, because the kinetic energy of a
particle is measured directly, and detection efficiency is 100% for all
masses. Here we describe the first commercial STJ mass spectrometer
intended for routine laboratory use. Known as Macromizer, this is a
MALDI ToF instrument with a16-pixel STJ detector array. Applications of
this technology to detection of very high mass proteins will be shown.
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