Proceedings

Day 2 - Wednesday, October 20, 2004

Current Strategies & Preferences for Metabolite Identification

The requirements for metabolite identification in drug discovery and development range from the rapid in vitro identification of major metabolic soft spots in early discovery through the exhaustive determination of the extract structure of low concentration metabolites formed in vivo in drug development studies. The session will cover a number of strategies for meeting these challenges utilizing in vitro and in vivo approaches for metabolite generation and the application of mass spectrometry and NMR spectrometry as both on line and static techniques.

An Integrated Analytical Approach for Determination of Metabolic Stability, Metabolic Soft-Spots and Rate of Metabolite Formation using a Hybrid Linear Ion Trap/Fourier Transform Mass SpectrometerM

Considerations for Metabolite Characterization Studies in Support of Drug Discovery

Nanoelectrospray as a Tool for Drug Metabolite Structure Elucidation

SepNMR: A System for the Isolation and Preparation of Trace Components from Mixtures for NMR Analysis

Biomarker Discovery

This session will address emerging technologies used for biomarker discovery with a focus on proteomics and metabolomics. Differential profiling and structure identification will be demonstrated in the context of biomarker discovery. The interplay of biochemistry, mass spectrometry and bioinformatics will be addressed and experiences during the process of technology development will be shared and discussed.

Molecular System Biology's Role in the Critical Path Initiative

Metabolomics: Applications in Safety Assessment and Biomarker Discovery

Differential Protein and Metabolite Profiling for Biomarker Discovery

Biomarker Roundtables

High Throughput ADME & Pharmaceutical Property Profiling

High throughput can sometimes give people cause to doubt the quality or practicality of data. This has been showcased in recent articles in the Wall Street Journal "Drug Industry's Big Push Into Technology Falls Short, Testing Machines Were Built to Streamline Research – But May be Stifling" and the response in C&E news "Drug Discovery, As High-Throughput Screening Draws Fire, Researchers Leverage Science to Put Automation into Perspective." This session will focus on how automation and computational tools have been leveraged to produce high quality ADME and pharmaceutical profiling data. In addition and more importantly demonstrate the approaches associated with turning the data into informed decision -making and applying this knowledge across projects.

Introduction to Session

Integrating ADME Screening Data into Discovery Decision-Making - The How and Why

Evolving Concepts in the Pharmaceutical Profiling Data Desired by Drug Discovery Teams and the Methods of Collaborating for Project Impact

Decision-Making Strategies in Drug Discovery

Vendor Session:

The vendor sessions provided a unique opportunity for the exhibitors to directly respond to industry updates on specific issues and needs that were delineated in the symposia sessions. This year, the issues and needs highlighted the balance between standardization and flexibility with regard to high throughput analysis. The Wednesday Vendor Session featured presentations on specific areas that deal with sample preparation, chromatography, analysis, informatics, and specialized services. Many thanks go to all of the participants for informative and stimulating presentations!

High Throughput Separations and Pharmaceutical Profiling by Multiplexed Capillary Electrophoresis with Absorbance Detection

Trace NMR Contract Services at Novatia

FAIMS – So What?

Advanced Applications Using the LEAP Product Lines

Equipment Acquisition Strategies (part 2)

Rapid High Throughput Compound Profiling Using the ExpressLC™

HPLC-Chip/MS: NanoLC/MS Made Easy

Dionex Today - From Nano to Semi-preparative LC for High Performance Separations of Proteins, Nucleic Acid, Oligosaccharides, and Small Molecules

IONICS HSID Interface for EP 10+ and API 3000™: Orthogonal Laminar Flow and Enhanced Desolvation

The Personal AutoNanospray™ System

High Throughput Quantitative Applications for Drug Discovery & Development by ACQUITY UPLC/Quattro Premier

Liquid Chromatography-based Assays for Secondary Screening

Endogenous Phospholipids and Matrix Effects in Bioanalysis

Combined Tissue Distribution, Tissue Quantitation, and Metabolite Profiling using QWBA, LC/FSD, and LC/MS/MS

Application of a new ESI-ion trap-time of flight mass spectrometer in the identification of Isomeric Drugs

Metabolite ID with Ultra-Fast Linear Ion Trap Mass Spectrometry

Variable Flow Nanobore LC-MS for the Analysis of Small Drug Molecules

Discovery, Identification and Quantitation of Biomarkers using iTRAQ™ Reagent Technology

A S D I BioSciences Company Profile

Custom GUI for Hamilton System

Poster Session, Exhibition & Social Hour – North Jersey ACS Mass Spectrometry Discussion Group

Keynote Lectures: