Proceedings

Day 3 - Thursday, October 21, 2004

Tissue Imaging – Localization of Drugs and Metabolites

The use of mass spectrometric techniques as an analytical tool has become standard in pharmaceutical research and development. Mass spectrometry is routinely applied throughout all phases of drug discovery and development, from the synthesis of new chemical entities (for structural characterization) to the analysis of lead compounds in clinical trials (for metabolite identification and pharmacokinetics). This session will discuss various MS-based imaging methodologies to provide useful information about the localization of a given target in biological tissues.

Mapping Small Molecules in Intact Tissue by Laser Microprobe Ion Trap Tandem Mass Spectrometry

Imaging Proteins in Tissues via MALDI Mass Spectrometry

Imaging Mass Spectrometry for Probing the Brain

Tissue Imaging Using MALDI Tandem Mass Spectrometry for Drug Candidates

Biomarker Evaluation

This session will focus on strategies and techniques used in the difficult, yet essential, process of translating candidate markers into tools that truly guide pre-clinical and clinical pharmacology. The importance of cross-functional partnerships, emerging technologies, and iterative learning will be emphasized.

Quantitation of Peptides & Protein Biomarkers by Mass Spectrometry

Analysis of Small Molecule Biomarkers

Establishing Pre-Clinical and Clinical PK/PD Relationships

Lunch/Roundtables – Compound Library Analysis and Profiling

The success of drug discovery research relies upon the quality of the corporate compound library. As compound stability can be affected by many factors, it is important to assess the quality of the library over time. Advances in analytical technologies made it possible. The discussion will be focused on assessing the quality of compound library with analytical technology.

Emerging Technologies and Applications

The last few decades has generated extraordinary technological advancements in medicine, science, transportation, engineering, and communication. These technologies have changed the way in which we live our personal lives as well as scientists’ ability to conduct research. New technologies are constantly being developed world wide in universities and companies, and speculating which ones will transform science is challenging. Several emerging areas of technology that should have a profound impact on the pharmaceutical industry will be discussed. These advances incorporate instrumentation, nanotechnology, and novel sample preparation. Each technology will be highlighted exemplifying the potential and promise for the pharmaceutical industry.

HPLC Chip Technology

Ion/Ion Methods for Peptide and Protein Sequence Analysis: Electron Transfer Dissociation and Beyond

Microwave-Enhanced Proteomic Applications – Rapid and Efficient Techniques for Protein Analysis

Wrap Up