Proceedings

Day 1 - Tuesday, October 19, 2004

Overview

Objectives/Format/Opening Remarks

Plenary

Quantitative and Ultra-sensitive High Throughput Proteomics

Biomarkers - Initiatives, Perspectives & Approaches

This session will initiate a dialogue on biomarker discovery and evaluation, setting the stage for two subsequent sessions which explore these topics in greater detail. Two distinguished speakers will share their experience and vision for how biomarker strategies and current technology can be deployed to optimize the discovery and development of novel therapeutic agents.

An Industrial Perspective on Biomarker Research: One Approach Taken

Biomarkers of Oxidative Stress

Roundtables - How Do We Set Priorities in Drug Discovery and Development?

Setting priorities is critical for successful research and the accomplishment of specific goals. Increased workloads and aggressive timelines make the task of prioritization both challenging and difficult. This informal session will highlight current industry perspectives and practices for setting priorities within drug discovery and development. Recent experiences with “how” actual priorities are set will be discussed from an analytical perspective. The goal will be to identify and recommend key elements that are necessary to achieve goals and foster successful collaborations.

Bradley Ackermann, Eli Lilly and Company
Edward Brewer, Tandem Labs
Chandra Natarajan, Sanofi Aventis
Steve Unger, Bristol-Myers Squibb

Outsourcing Trends - Emerging Business Models & Overseas Partners

The industry for the outsourcing of bioanalytical analysis from the pharmaceutical sector has been an arena of considerable change in recent years. Riding the crests and troughs of its R&D partners, the 1990s were a time of great growth for the outsourcing sector, but in a climate of weak pipelines, uncertain future of blockbuster drug candidates, and reduced pharmaceutical R&D budgets this sector has been required to reassess its operational strategies. This session will initiate a dialogue on outsourcing strategies and explore this topic from two perspectives - "Big Pharma" and Contract Research Organizations.

The Impact of Value Enhancement Initiatives to Outsourcing Strategies

Outsourcing and Offshoring DMPK Studies - The Pros and Cons

Cost Benefit Analysis

High Throughput Analysis & Information Management Strategies

The purpose of this session will be to examine the challenges that arise due to operating in a high-throughput mode and to look at some solutions that have been developed to meet those challenges. For example, all high-throughput groups must develop solutions for keeping track of the large numbers of samples coming through the laboratory, developing generic sample treatment and analysis methods, and automating data collection and processing. Also, data quality standards have to be implemented with a tradeoff between minimizing the number of data items that a human must examine and maximizing the confidence of the results for the purpose of making a business decision. Most groups use a combination of both commercial and in-house developed hardware and software.

Flexible Automation Tools for Drug Metabolism: Workstation and Fully Automated Approaches for in vitro and PK Studies

Automatic Reduction of Analytical Data System

High-Throughput LC-MS – A Total Package

Vendor Session:

The vendor sessions provided a unique opportunity for the exhibitors to directly respond to industry updates on specific issues and needs that were delineated in the symposia sessions. This year, the issues and needs highlighted the balance between standardization and flexibility with regard to high throughput analysis. The Tuesday Vendor Session featured presentations on specific areas that deal with sample preparation, chromatography, analysis, informatics, and specialized services. Many thanks go to all of the participants for informative and stimulating presentations!

Membrane Applications

High Throughput Protein Analysis

Intact Biomolecule MS Analysis

Keys to Restek's Success

Five Minutes of FAIMS

What LEAP Stands For and Summary of New Products

Asset Management and Equipment Acquisition

Biomarker Identification with the NanoLC System

Dionex Today

New Developments at Waters

High S/N Interface for Atmospheric Pressure Ionization

MALDI Imaging Software for QSTAR® XL System

A New 3-D Plastic Nanospray Chip

µPLC for Discovery Analytical Chemistry

The Chemical Inkjet Printer-ChIP

Linear Ion Trap and FTICR Mass Spectrometry for Biomarker Discovery

Automated Variable Flow Gradient Nanobore LC-MS: Feedback Controlled Electrospray

Poster Session/Social Hour