CPSA Digest 2004

Day 2 - Wednesday, October 20, 2004

Vendor Session - ACQUITY UPLC™-Quattro Premier ™

• ACQUITY UPLC™-Quattro Premier ™
  • ACQUITY UPLC™ Column: 1.7 mm, 2.1x50 mm
    • Flow rate:
    • 0.6 ml/minute, no splitting for regular exp.
    • 1 ml/minute with splitting, 400 ml/minute into MS for ESCi
  • Quattro Premier:
    • Minimum dwell time: 5 ms
    • Minimum inter-channel/inter-scan delay: 5 ms
    • Minimum inter-mode delay: 20 ms
    • Multi-mode ionization: Standard
  • Tandem Quadrupole Quantification
    • Improved Speed - Alprazolam in precipitated rat plasma, 10 ng/mL, 5 ml Injection
    • Higher Sensitivity - ACQUITY UPLC™Column 2.1 x 50 mm, 1.7 mm, 0.6 ml/min., no flow splitting; Quattro Premier MS, MRM, Simultaneous polarity switching
    • Linearity - 3 Injections per concentration in precipitated rat plasma (Prednisolone, 361.1>343.5, ESI+ and Ibuprofen, 205.2>161.3, ESI-)
    • System Robustness - 10 ng/mL Standard Spiked in Precipitated Rat Plasma (Alprazolam, Internal Calibration, 5 ms Dwell Time, 5 ms Delay)
    • Negligible Carryover
    • Multi-mode Ionization: ESCi - Simultaneous Electrospray/APCI

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