CPSA Digest 2004

Day 2 - Wednesday, October 20, 2004

Vendor Session - Application of New ESI Ion Trap Time of Flight Mass Spectrometer in the Identification of Isomeric Drugs

• LCMS IT TOF mass spectrometer
  • Mass Errors (external calibration) - Average error = 3.5 ppm
  • External Calibration Stability (24 hrs) - No significant drift over 24 hours
  • Fast Polarity Switching: MS - Positive ion/Negative ion
  • Protein ID - Extensive sequence coverage combined with superior mass accuracy and resolution provides high confidence identification
• Summary
  • Mass accuracy and mass resolution remains constant in all MS modes
  • The thermally stable design of the flight tube leads to improved mass calibration stability over time (no significant drift over 24 hours)
  • Fast polarity switching allows the identification of analytes not identified by single polarity analysis
  • High mass accuracy and resolution combined with multiple MS fragmentation steps provides increased confidence in the identification of small molecules and proteins

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