CPSA Digest 2004

Integrated Approaches in Drug Discovery & Development: Turning Measurements to Medicine

Day 1: Proceedings | Plenary
Day 2: Proceedings
Day 3: Proceedings

CPSA 2004 Sponsors

Past CPSA Digests
CPSA Digest 2000
CPSA Digest 2001
CPSA Digest 2002
CPSA Digest 2003
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Day 2 - Wednesday, October 20, 2004

Vendor Session - Metabolite ID with Ultra-Fast Linear Ion Trap Mass Spectrometry

Rich Klein, Thermo Electron

LTQ Ion Trap Mass Spectrometer
- Improved Cycle Time
  - More spectra acquired across narrow chromatographic peaks
  - Increased information content
  - Acquisition of MS and MS2 spectra from co-eluting metabolites
- Acquisition of MS2 spectra from low- level metabolites in complicated matrices
  - Increased confidence in structural assignments
  - Extraordinary spectral quality for individual MS2 scans
- Improved Sensitivity
  - Lower levels of metabolite detected
  - Less sample preparation required
  - Less re-running of samples required