| Monday, October 17 |
| 8:30 am - 4:30 pm |
Short Courses
Gallery/Lower Lobby Level – Board Rooms |
| |
Chromatographic (HPLC and SFC) and
Electrophoretic (CE) Method Development for LC/SFC/CE-MS
Instructors: Shane Needham, Alturas Analytics; Yining Zhao, Pfizer |
| |
Peptide Sequencing & Protein Identification by LC/MS/MS Ion Trap and
Fourier Transform Mass Spectometry
Instructors: Nathan A. Yates, Merck Research Laboratories;
Gary A. Valaskovic, New Objective |
| |
Metabolic Profiling: Principles and Practice
Instructors: Andrew Nicholls, GlaxoSmithKline;
John P. Shockcor, Waters Corporation |
| 5:30 pm - 7:30 pm |
Reception & Registration
Water’s Edge Terrace – Atrium Lobby |
| |
| Tuesday, October 18 |
| 7:30 am - 8:30 am |
Registration & Continental Breakfast
Regency Ballroom |
| 8:30 am - 8:35 am |
Welcome
Mike S. Lee, Milestone Development Services |
| 8:35 am - 9:00 am |
Conference Overview: Objectives, Format & Opening Remarks
Bradley L. Ackermann, Eli Lilly and Company
|
| 9:00 am- 9:45 am |
Plenary Lecture: Enabling Biology Through Analytical Innovation: Tissue
Imaging in the Ambient Environment Using DESI Mass Spectrometry
R. Graham Cooks, Purdue University
|
| 9:45 am - 10:00 am |
Break/Roundtables |
| 10:00 am - 11:15 am |
Biomarkers - Proteomics Strategies
Discussion Leader: Kevin Duffin, Eli Lilly and Company;
Bradley L. Ackermann, Eli Lilly and Company
Application of a Hybrid Linear Ion Trap/Fourier Transform
Mass Spectrometer for Biomarker Discovery
Ronald Hendrickson, Merck Research Laboratories
Application of Targeted Proteomics for Biomarker Discovery
Kevin Duffin, Eli Lilly and Company
|
| 11:15 am - 11:30 am |
Break/Roundtables |
| 11:30 am - 12:45 pm |
Complimentary Lunch/Roundtables- Metabolic Identification: Emerging
Strategies to Make Better Use of Time and Resources
Discussion Leader: Andrea Sefler, GlaxoSmithkline
Metabolite ID Strategies Using QTrap and QStar Hybrid Mass Spectrometers
Tanya Gamble, ABI/MDS Sciex
Comparing Mass Defect and Accurate Mass Profile Filtering for Metabolite ID
Yongdong Wang, Cerno Bioscience
Streamlining the Metabolic Profiling Workflow through MetWorks and Mass Frontier
Brenda Kesler, Thermo Electron
|
| 12:45 pm - 2:15 pm |
Chromatography
Discussion Leader: Steve Fields, ALZA Corporation
Chip Technology, Nanoliters and Picoliters - Miniaturization of
(Bio)analytical Chemistry Methods
Andreas Manz, Institute for Analytical Sciences
Separation Based Sensors for Pharmaceutical and Biomedical Analysis
Susan Lunte, University of Kansas
Ultra-High Performance Separation: Hype or Hope?
Yining Zhao, Pfizer
|
| 2:15 pm - 3:15 pm |
Poster Session/Roundtables
Regency Foyer
Chairs: Praveen Balimane, Bristol-Myers Squibb;
James Stephenson, RTI International
|
| 3:15 pm - 4:30 pm |
Bioanalytical - Current Strategies
Discussion Leader: Jing-Tao Wu, Millennium Pharmaceuticals
Bioanalytical Strategies from Discovery through Development
Steve E. Unger, Bristol-Myers Squibb
Sustaining Extensive ADME Screening in Discovery
Mark J. Cole, Pfizer
Enabling Biology through ‘Fit-for-Purpose’ Method Validation
for Bioanalysis of Macromolecule Drugs and Biomarkers
Jean Lee, MDS Pharma Services
|
| 4:30 pm - 5:00 pm |
Break/Roundtables - Exhibits Open |
| 5:00 pm - 6:00 pm |
Vendor Session
Discussion Leader: Kathleen Anderson, Novatia |
| 6:00 pm - 7:00 pm |
Social Hour
|
| |
| Wednesday, October 19 |
7:30 am - 8:30 am |
Registration & Continental Breakfast
Regency Ballroom |
| 8:30 am - 9:45 am |
Pharmaceutical Properties - Compound Library Analysis and Profiling
Discussion Leader: Dalin Nie, AstraZeneca; David J. Semin, Amgen
Quality Enhancement of Large Chemically Diverse Compound Libraries -
The Impact of Measuring Concentrations by CLND
Olga Issakova, Nanosyn
Evaluation of Sample Integrity in Compound Management
Manori Turmel, AstraZeneca
Methods and Applications of Pharmaceutical Profiling Assays
in Lead Selection and Optimization
Li Di, Wyeth
|
| 9:45 am- 10:15 am |
Break/Roundtables - Exhibition Open |
| 10:15 am - 11:30 pm |
Biomarkers - Metabonomics Strategies
Discussion Leader: Kevin Duffin, Eli Lilly and Company;
Bradley L. Ackermann, Eli Lilly and Company
Practical Considerations for the Study of Lipidomics Using Mass
Spectrometry
Kathleen Harrison, University of Colorado Health Sciences Center
Probing Biofluids with Statistics: Tips and Strategies
John P. Shockcor, Waters Corporation
Research Applications of Metabolomic Datasets
Chris Beecher, Metabolon
|
| 11:30 pm - 11:45 am |
Break/Roundtables |
| 11:45 am - 1:00 pm |
Complimentary Lunch/Roundtables – Incorporating Metabonomics into
Pharmaceutical Discovery & Development
Discussion Leaders: Kevin Duffin, Eli Lilly and Company;
Bradley L. Ackermann, Eli Lilly and Company
Chris Beecher, Metabolon
Kathleen Harrison, University of Colorado Health Sciences Center
Doug Heath, Phenomenome
William Schaefer, Merck Research Laboratories
John P. Shockcor, Waters Corporation
|
| 1:00 pm - 2:15 pm |
Bioanalytical - Driving Technologies and Methodologies
Discussion Leader: Jing-Tao Wu, Millennium Pharmaceuticals
Addressing Phospholipid Based Matrix Effects in Bioanalysis:
Bringing New Technology to Bear
Patrick Bennett, Tandem Labs
High-Throughput Bioanalysis with FAIMS
Adam Brockman, Millennium Pharmaceuticals
Evaluating the Advantages of Chip-Based Infusion Nanoelectrospray
MS/MS for the Quantification of Small Molecules
Enaksha Wickremsinhe, Eli Lilly
|
| 2:15 pm - 3:15 pm |
Poster Session/Roundtables
Regency Foyer
Chairs: Praveen Balimane, Bristol-Myers Squibb;
James Stephenson, RTI International
|
| 3:15 pm - 4:45 pm |
Vendor Session
Discussion Leaders: Kathleen Anderson, Novatia |
| 4:45 pm - 5:00 pm |
Break |
| 5:00 pm - 6:00 pm |
Exhibition & Social Hour |
| 6:00 pm - 7:30 pm |
Dinner- North Jersey ACS Mass Spectrometry Discussion Group |
| 7:30 pm - 7:45 pm |
ACS Announcements
CPSA - Distinguished Analytical Scientist Award Presentation |
| 7:45 pm - 9:00 pm |
Keynote Lectures:
Modern Separation Science: Quo Vadis? -- The Pursuit of Higher
Resolution and Higher Speed Separation in Drug Discovery
and Development
Yining Zhao, Pfizer
Discovery and Clinical Validation of Serum Biomarkers for
Disease Diagnosis
John T. Stults, Predicant Biosciences
|
| |
| Thursday, October 20 |
| 7:30 am - 8:30 am |
Registration & Continental Breakfast
Regency Ballroom |
| 8:30 am - 10:00 am |
Pharmaceutical Properties - HT ADME
Discussion Leader: Jeffrey L. Dage, Eli Lilly and Company
ADME in Drug Discovery: What to Profile? When to Profile?
How to Profile? Or is it Just Indiscriminate Stamp-Collecting?
Daniel B. Kassel, Takeda San Diego, Inc.
More Throughput Does Not Equal Less Flexible or Less Believable Data
Robyn A. Rourick, Kalypsys
|
| 10:00 am - 10:30 am |
Break/Roundtables |
| 10:30 am - 12:15 pm |
Biomarkers - New Technologies and Approaches
Discussion Leader: Kevin Duffin, Eli Lilly and Company;
Bradley L. Ackermann, Eli Lilly and Company
LC/MS Can Replace Traditional Radioligand Methods to Quantify
Tracer Distribution in Preclinical in vivo Brain Receptor
Occupancy Experiments
Lee Phebus, Eli Lilly and Company
The Frontier of Top Down Mass Spectrometry for Native Proteins
and Biomarkers
Andrew J. Forbes, University of Illinois
|
| 12:15 pm - 1:30 pm |
Lunch/Roundtables - NMR Analysis: Emerging Analysis Strategies and Methodologies
Discussion Leaders: David J. Detlefsen, Novatia;
István Pelczer, Princeton University |
| 1:30 pm - 3:00 pm |
Bioanalytical - Exploratory Technologies
Discussion Leader: Jing-Tao Wu, Millenium Pharmaceuticals
An Analysis of the Technology Required to Achieve High Throughput
LC/MALDI MS/MS for Bioanalytical Applications
Tom Covey, MDS Sciex
PicoSpray: Ultra-low Flow Rate Nanospray as an LC/MS Calibrator
for the Quantitative Estimation of Metabolite Levels in Drug
Discovery
Gary A. Valaskovic, New Objective
Characterization of DART as a Potential Ionization Technique
for High-Throughput Bioanalysis
Jing-Tao Wu, Millennium Pharmaceuticals
|
| 3:00 pm - 3:15 pm |
Wrap Up
Bradley L. Ackermann, Eli Lilly and Company |
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