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CPSA Digest 2006
Shaping the Pharmaceutical Landscape with Engaged Analytical Sciences
Overview
This year’s annual meeting featured open discussion on emerging opportunities to significantly
impact drug discovery and development.
Take Home Messages & Quotes
Technology and applications: The advancement of analytical technologies combined
with the understanding of specific applications emerges as critical requisites for
analytical chemists.
Opening Remarks
The analytical sciences are both universal and engaged. “We can shape the
pharmaceutical landscape with engaged analytical sciences!” – Jing-Tao Wu,
Millennium Pharmaceuticals.
Plenary Lecture
“You have to know where you’ve been in order to recognize that you’re going anywhere
else” – Mark Powell, Bristol-Myers Squibb.
Take Home Messages & Implementation from FDA/AAPS Bioanalytical Workshop (Crystal City 3)
“… QC samples DO NOT always replicate true study samples. (So) What is the risk?” –
Stephen Lowes, Advion BioServices
Drug Discovery – Proteins and Early Biology, Chemistry, and Biomarkers
“… the application of sub-two micron particles to fast pharmaceutical separations has challenges
that need to be considered.” – Jeff Dai, Bristol-Myers Squibb
Discovery Strategy: The Minimalist Approach Versus the Fail Faster Model
“Is there a balance of risk (to) minimize discovery costs but test clinical
hypotheses?” – Jeff Dage, Eli Lilly and Company
ADME-TOX: Predictive Toxicology, Reactive Metabolites, and Pharmacokinetics and Pharmacodynamics
“Not all hERG channel blockers induce torsades de pointes (TdP) because they may
modulate other channels that counteract the effects on hERG!” – Dinah Misner,
Roche Palo Alto
Clinical Development – Measurement of Drug and Measurement of Drug Effects
“Even experienced analytical chemists cannot resist the temptation to
demonstrate innovation and creativity by developing “high throughput
screening” methods.“ – Lucinda Cohen, Pfizer
Pharmaceutical Sciences – Analytical New Strategies and Analytical New Technologies
“Current status of VHPLC should be promoted as a time saving technique, not necessarily
an efficient one. “ – Todd Maloney, Pfizer
Emerging New Technologies
Interest continues to focus on the effective integration of new technologies with
emerging workflows for sample analysis.
Sponsor Workshops
Innovations for increased sample throughput and analytical performance were featured in
workshops hosted by Agilent Technologies, Applied Biosystems/MDS Sciex, and Phenomenex.
Keynote Lectures
A very special evening was celebrated with the North Jersey Mass Spectrometry
Discussion Group and North Jersey Chromatography Group. The combined event
featured vendor session talks, exhibition, social hour, dinner and two keynote lectures.
Ion Formation from Complex Solutions: Understanding Matrix Effects and Ionization Suppression
Richard C. King, Merck Research Laboratories
Markers of Cancer Using a Liquid Proteomics Approach
David M. Lubman, University of Michigan
Distinguished Analytical Scientist Award
Congratulations to Rick King of Merck Research Laboratories for receiving the
Distinguished Analytical Scientist Award presented at CPSA 2006!
Vendor Session - Technology & Solutions
An impressive array of products and services were introduced during
the exhibition and vendor session.
Company Descriptions
Need more information? Use this reference for contact information and
company descriptions.
Poster Session Abstracts
The poster sessions featured topics on analytical separations,
proteomics, software, and bioanalysis.
CPSA 2007!
Mark your calendar for the 10th Annual Symposium on Chemical and
Pharmaceutical Structure Analysis (CPSA 2007)! October 22-25, 2007;
Bucks County Sheraton Hotel, Langhorne, Pennsylvania.
CPSA 2006 Complete Digest
Download the complete CPSA 2006 Digest here.
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