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Overview |
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Call for Papers |
Short Courses |
Program |
Registration |
Job Postings |
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Preliminary Program Agenda
| Monday, October 16 |
| 5:30 pm - 7:30 pm |
Reception and Registration
Water's Edge Terrace - Atrium Lobby, Hyatt Regency Princeton |
| Tuesday, October 17 |
| 7:30 am - 8:30 pm |
Registration and Continental Breakfast
|
| 8:30 am - 8:35 am |
Welcome
Mike S. Lee, Milestone Development Services |
| 8:35 am - 9:00 am |
Conference Overview: Objectives, Format & Opening Remarks
Jing-Tao Wu, Millennium Pharmaceuticals |
| 9:00 am- 9:45 am |
Plenary Lecture – Analytical Chemistry: A Changing Paradigm of
Advanced Process Models, Tools and Technologies in R&D
Mark L. Powell, Bristol-Myers Squibb
|
| 9:45 am - 10:00 am |
Break/Roundtables |
| 10:00 am - 11:15 am |
Drug Discovery - Proteins and Early Biology
Discussion Leaders: Dieter Drexler, Bristol-Myers Squibb;
Mark E. Hail, Novatia
The Biochemistry of RNA Interference (RNAi): Impact on Design,
Synthesis, and Modification of RNA Duplexes for in vitro and in vivo Use
Mark Behlke, Integrated DNA Technologies
Proteomics in the Pharmaceutical Landscape: The Future Role of Mass Spectrometry
James L. Stephenson, RTI International
Bringing Back Nature to Drug Discovery - Natural Molecules in an
Antibacterial Program
Mark O'Neill Johnson, Sequoia Sciences
|
| 11:15 am - 11:30 am |
Break/Roundtables |
| 11:30 am - 12:45 pm |
Complimentary Lunch/Roundtables- Discovery Strategy: The Minimalist
Approach Versus the Fail Faster Model
Discussion Leaders: Jeffrey L. Dage, Eli Lilly and Company;
Peter King, Quest Pharmaceutical Services
Roy Vaz, Sanofi-Aventis
|
| 12:45 pm - 2:00 pm |
ADME TOX – Predictive Toxicology
Discussion Leaders: Jing-Tao Wu, Millennium Pharmaceuticals;
Cindy Xia, Millennium Pharmaceuticals
Accurate Prediction of Human Drug Toxicity:
Challenges and Promising Approaches
Albert Li, The ADMET Group
New Approaches to Toxicity Screening Using Biosensor Arrays
James F. Rusling, University of Connecticut
Predicting QT Prolongation: Assessing hERG and
Other Cardiac Ion Channels Early
Dinah Misner, Roche Palo Alto
|
| 2:00 pm - 3:00 pm |
Poster Session/Roundtables
Chairs: Praveen Balimane, Bristol-Myers Squibb;
James L. Stephenson, RTI International
|
| 3:00 pm - 4:15 pm |
Clinical Development – Measurement of Drug
Discussion Leaders: Bradley L. Ackermann, Eli Lilly and Company;
Nalini P. Sadagopan, Pfizer
DMPK’s Love/Hate Relationship with Protein Binding
Lucinda Cohen, Pfizer Global R&D
Use of Highly Sensitive Bioanalysis in Human Microdosing Studies: How Does It All
Fit Together in Drug Discovery and Development?
Ajai Chaudhary, Eli Lilly and Company
|
| 4:15 pm - 4:45 pm |
Break/Roundtables |
| 4:45 pm - 6:00 pm |
Pharmaceutical Sciences - Analytical New Strategies
Sponsored by Agilent Technologies and held in conjunction
with the North Jersey ACS Chromatography Discussion Group
Discussion Leader: Yining Zhao, Pfizer
Opening Remarks and Award Presentation - North Jersey
Chromatography Group
Mariann Neverovitch, NJCG Chairwoman, Bristol-Myers Squibb
Providing Information-Rich
Solutions for Pharmaceutical Product Development through
the use of Innovative Technologies
Brian E. Winger, Thomas M. Zennie, Steven W. Baertschi,
Andreas Kaerner, Eli Lilly and Company
Impact and Direction of Enabling
Technologies within Analytical R&D at Pfizer-UK
Paul Ferguson, Pfizer Global R&D
Challenges and Opportunities in
Developing High Throughput Assays for Biocatalysis and Green
Chemistry
Junhua Tao, BioVerdant, Inc.
|
| 6:00 pm - 8:00 pm |
Sponsor Hospitality - Evening Workshop (Gallery/Lower Level)
Held in conjunction with the North Jersey ACS Chromatography
Discussion Group
Agilent Technologies (Witherspoon A/B)
Innovation for Improving Performance and Throughput
in LC/MS Analyses – or “How did They Do That???”
Doug McInytre, Agilent Technologies
Integrated HPLC-Chips for Nanospray LC/MS
Stephan Buckenmaier, Agilent Technologies
High Speed, High Resolution HPLC for Method Development
Utilizing Sub Two Micron Technology for Optimizing Time, Resolution and Sensitivity
for Results on Time
Maureen Joseph, Agilent Technologies
Applied Biosystems/MDS Sciex (Stockton A/B)
Towards Improving Quantitative LC/MS/MS: The Combination
of Multi-Targeted Analysis and High Throughput Chromatography
Daniel Temponi Lebre, Applied Biosystems/MDS SCIEX
Phenomenex (Einstein A/B)
Automated Rapid Robust SPE Method Development Using A Novel
Polymeric 96-Well Plate
Yanick Bouchard, OptimiLab
Ultra-Fast Gradient LC Separations Using Your Existing
LC/MSn: Applying the theory to get results
Mark Hayward, Lundbeck Research
Addressing Challenges with Implementing Routine Use of
Ultra-High Pressure LC in Pharmaceutical Development
Qinggang Wang, Bristol-Myers Squibb
Fast LC Theory & Practice: Achieving consistent high
performance, high speed results on newer and existing HPLC
instrumentation
Jason Anspach, Phenomenex
|
| |
| Wednesday, October 18 |
7:30 am - 8:30 am |
Registration & Continental Breakfast
|
| 8:30 am - 9:45 am |
Drug Discovery – Chemistry
Discussion Leaders: Dieter Drexler, Bristol-Myers Squibb;
Mark E. Hail, Novatia
Smart, Active Micro-devices for Coordinating and
Performing the Sample Workflow - Hyphenating the Technology
Thomas Londo; Paul Grippo; Daniel Bantz; Paul Horvat; Frank Sylva; Angela Tseng;
Maxwell MacLean; Kenneth Wynn; Michael Portela, Donald McNeil
Inhibitor Screening by Mass Spectrometry
Ken Greis, University of Cincinnati
Challenges in Physical Chemical Property Characterization
Manuel Sanchez-Felix, Eli Lilly and Company
|
| 9:45 am- 10:15 am |
Break/Roundtables |
| 10:15 am - 11:30 pm - |
ADME TOX –The Unsolved Mystery: Reactive Metabolites
Discussion Leaders: Jing-Tao Wu, Millennium Pharmaceuticals;
Cindy Xia, Millennium Pharmaceuticals
Optimization in Screening Reactive Metabolites by LC-MS/MS
Zhengyin Yan, Johnson and Johnson
Screening for Reactive Drug Metabolites
During Early Pharmaceutical Drug Discovery
John R. Soglia, Pfizer
Reactive Metabolites in Toxicology:
A Focus on Protein Adducts
John Erve, Wyeth Pharmaceuticals, Inc.
|
| 11:30 am - 11:45 am |
Break/Roundtables |
| 11:45 am - 1:00 pm |
Complimentary Lunch/Roundtables – AAPS/FDA Bioanalytical Workshop:
Take Home Messages and Implementation
Discussion Leader:Stephen Lowes, Advion BioSciences
A Summary to Date of Incurred Sample Reanalysis Strategies
Stephen Lowes, Advion BioSciences
Selection of Calibration Curve and QC Ranges for Bioanalytical LC-MS/MS
Naidong Weng, Bristol-Myers Squibb
Partial Validations, Method Transfers and Stability – What are the Requirements?
Mike Buonarti, Alta Analytical Laboratory
|
| 1:00 pm - 2:30 pm |
Clinical Development – Measurement of Drug Effects
Discussion Leaders: Bradley L. Ackermann, Eli Lilly and Company;
Nalini P. Sadagopan, Pfizer
Drug Development Using a PK/PD Model Linking Drug Exposure to Analgesic Response
Ann Remmers, Pfizer Global R&D
Exploring the Potential of LC-SRM for Quantification of Peptide
and Protein Biomarkers
Bradley L. Ackermann, Eli Lilly and Company
The Development, Validation, and Application of Biomarkers for
Decision-Making and Model Based Drug Discovery and Development
Gabriella Szekely-Klepser, Pfizer Global R&D
|
| 2:30 pm - 3:30 pm |
Poster Session/Roundtables - Ballroom Foyer
Chairs: Praveen Balimane, Bristol-Myers Squibb;
James L. Stephenson, RTI International
|
| 3:30 pm - 4:45 pm |
Vendor Session
Held in conjunction with the North Jersey ACS Mass Spectrometry Discussion Group
Discussion Leader: Mark Hayward, Lundbeck Research USA
RTI--The $500 Million CRO You've Never Heard Of
Jenn McWilliams, RTI International
Increased “Use-time” While Using Less of Your Time
Michael DeMayo, Dionex Corporation
Automated component extraction and [M+H]+ or [M-H]- assignment for
metabolite or impurity identification
Margaret Antler, ACD Labs
Enhancing Ion Extraction in LC-MS-MS: Modelling and Experimentation
Ionics EP Q+ Upgrade System for API 2000
Dragan Vuckovic, IONICS Mass Spectrometry Group
Advances in a Novel Microfluidic Technology for Nanospray Enabled LC-MS
Gary Valaskovic, New Objective
New Technology Directions
Tom Covey, Applied Biosystems/MDS Sciex
TriVersa NanoMate: Extending Experimental Dynamic Range for
LC/MS Applications Through Nanoelectrospray of LC Fractions
Gary A. Schultz, Advion
Enabling DART (Direct Analysis in Real Time) for the LC/MS/Masses
Brian Musselman, Ion Sense
Direct Analysis in Real Time (DART) on the JEOL High Resolution AccuTOF MS System
Chip Cody, JEOL USA
Long-Term Data Access Using Open Standards
Randall Julian, Indigo BioSystems
Confident empirical formula determination in Drug Metabolism
using Exact mass LC-MS and MS/MS, leveraging a key 3rd dimension
of information : True Isotope Patterns with Sigma Fit
Doug Boyd, Bruker Daltonics Inc.
Novel High-Throughput Metabolite ID
Lily Li, Tandem Labs New England
Phenomenex: Focus on HPLC Column Technology
Tivadar Farkas, Phenomenex
Maintaining Sensitivity with Ultra-fast Scanning in a Single
Quadrupole LC/MS
Tony Brand, Agilent Technologies
Introducing a Unique TOF-TOF MALDI Mass Spectrometer
Sean Randall, Shimadzu Biotech
Structure Profiling Services At Novatia
Jeff Whitney, Novatia
The People Behind the Name
Martin Steel, McKinley Scientific
Parallel Capillary LC for Method Development
Laurie Allen, Eksigent Technologies
|
| 4:45 pm - 5:00 pm |
Break |
| 5:00 pm - 6:00 pm |
Exhibition & Social Hour
Held in conjunction with the North Jersey ACS Mass Spectrometry Discussion Group
|
| 6:00 pm - 7:30 pm |
Dinner- North Jersey ACS Mass Spectrometry Discussion Group |
| 7:30 pm - 7:45 pm |
ACS Announcements
CPSA - Distinguished Analytical Scientist Award Presentation |
| 7:45 pm - 9:00 pm |
Keynote Lectures:
Sponsored By: Applied Biosystems/MDS Sciex and Shimadzu Biotech
Ion Formation from Complex Solutions: Understanding Matrix
Effects and Ionization Suppression
Richard C. King, Merck Research Laboratories
Markers of Cancer Using a Liquid Proteomics Approach
David M. Lubman, University of Michigan
|
| |
| Thursday, October 19 |
| 7:30 am - 8:30 am |
Registration & Continental Breakfast
|
| 8:30 am - 10:00 am |
Drug Discovery – Biomarkers
Discussion Leaders: Dieter Drexler, Bristol-Myers Squibb;
Mark E. Hail, Novatia
Evaluation of Chromatography Using sub
2 µm Particles for Fast Pharmaceutical Analysis - What Are
the Real Benefits?
Jeff Dai, Bristol-Myers Squibb
Metabonomic Applications in Drug Discovery
Michael Reily, Pfizer
Protein-Based Biomarker Discovery
Nathan A. Yates, Merck Research Laboratories
|
| 10:00 am - 10:30 am |
Break/Roundtables |
| 10:30 am - 12:15 pm |
Pharmaceutical Sciences - Analytical New Technologies
Discussion Leader: Yining Zhao, Pfizer
The Four M’s of Protein Analytical Chemistry;
Minimalist, Miniaturization, Multiplexing, and Managing the Analytical
Technology for the Characterization of Proteins
Chuck Demarest, Rob Dufield, Nathan Lacher, Jeff Schneiderheinze,
Yining Zhao and Gary Bild, Pfizer Global R&D
MS as a Core Technology for Developing Analytical
Control Strategies for Small Molecule Pharmaceutical Development
Todd Gillespie and Brian Winger, Eli Lilly and Company
Evaluation of Very High Pressure Liquid Chromatography Instrumentation
for Pharmaceutical Analysis
Todd D. Maloney and Robert Bujalski, Pfizer Global R&D
|
| 12:15 pm - 1:30 pm |
Lunch/Roundtables - Emerging New Technologies
Discussion Leaders: Mark J. Cole, Pfizer;
Jonathan L. Josephs, Bristol-Myers Squibb
Tom Covey, Applied Biosystems/MDS Sciex
Thomas Londo, Parker Life Sciences
|
| 1:30 pm - 3:00 pm |
ADME TOX – Pharmacokinetics & Pharmacodynamics
Discussion Leaders: Jing-Tao Wu, Millennium Pharmaceuticals;
Cindy Xia, Millennium Pharmaceuticals
Drug Transporters and Tissue Distribution
Cindy Xia, Millennium Pharmaceuticals
Whole-Body, Micro-Autoradiography, and Metabolite Profiling: An
Integrated Approach for Studying Tissue Distribution, Metabolism,
and Transport of Compounds Across Tissue Compartments
Eric Solon, Quest Pharmaceutical Services
Towards Free Concentration Measurement in Target Tissues
Mark Qian, Millennium Pharmaceuticals
|
| 3:00 pm - 3:15 pm |
Wrap Up
Jing-Tao Wu, Millennium Pharmaceuticals |
|
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