| Monday, October 27 |
| 8:30 am - 4:30 pm |
Short Courses – Bucks County Sheraton Hotel
(2nd Floor Boardroom Lobby Level)
- Method Development for LC/MS: Traditional Approaches and Emerging Trends
- Roger Hayes, Schering-Plough
- Shane Needham, Alturas Analytics
- High Throughput Drug Discovery Support: LC/MS Strategies for Method Development,
Profiling and Workflow Solutions
- Mark Hayward, Lundbeck Research USA
- Ken Lewis, OpAns
- Is Poor Bioavailability in Early drug Discovery a Problem and If So, How Can We Solve It?
- Sample Preparation for Non-Traditional and Traditional Biological Matrices: Mass Spectrometry
Quantitation from Organic Molecules to Peptides/Proteins
- Min Chang, Biogen Idec
- Qin Ji, Covance
|
| 5:30 pm - 7:30 pm |
Reception and Registration
(Princeton II 2nd Floor Boardroom Lobby Level)
|
| 8:30 pm - 10:00 pm |
Sponsors Dinner Event
|
| Tuesday, October 28 |
| 7:30 am - 8:30 am |
Registration and Continental Breakfast (University Ballroom Foyer)
|
| 8:30 am - 8:35 am |
Welcome (University II Ballroom)
Mike S. Lee, Milestone Development Services |
| 8:35 am - 9:00 am |
Objectives, Format & Opening Remarks (University II Ballroom)
Lucinda Cohen, Merck Research Laboratories |
| 9:00 am- 9:45 am |
Plenary Lecture (University II Ballroom)
Mass Spectrometry of Synthetic Polymers: Some Challenges and Some Successes
David M. Hercules, Centennial Professor of Chemistry Emeritus, Vanderbilt University
|
| 9:45 am - 10:00 am |
Break/Roundtables |
| 10:00 am - 11:15 am |
Excellence in Bioanalysis through Automation (University II Ballroom)
Discussion Leader: Steven Michael, Pfizer
Improving Bioanalytical Communication, Sample Handling, Data Reporting and
Decision Making with a Custom Informatics Tool
John P. Walsh, Charles E. Taylor, Qiner Yang and Robyn A. Rourick, Kalypsys, Inc.
Process Improvement and Increased Productivity through the Introduction of Centralized,
Automated Sample Preparation into a Generalist Model
Chris Holliman, Dave Weller, Max Tella, and Lisa Buchholz, Pfizer
|
| 11:15 am - 11:30 am |
Break/Roundtables |
| 11:30 am - 12:45 pm |
Complimentary Lunch/Roundtables – Insourcing, Outsourcing and Offshoring (University II Ballroom)
Discussion Leader: Dieter Drexler, Bristol-Myers Squibb
Min Zhong, Pfizer
- Adrienne Tymiak, Bristol-Myers Squibb
- Min Zhong, Pfizer
|
| 12:45 pm - 3:00 pm |
Poster Session/Roundtables (University I Ballroom)
Session Chairs: Michelle Dennehy, GlaxoSmithKline
James L. Stephenson, RTI International
Matthew E. Szapacs, GlaxoSmithKline
Tracie Williams, Centers for Disease Control & Prevention
|
| 2:00 pm – 3:00 pm |
TBA (Princeton I – 2nd Floor Boardroom Lobby Level)
High Throughput Applications – Fast Chromatography (Princeton II – 2nd Floor Boardroom Lobby Level)
- Roger N. Hayes, Schering-Plough
- Mark J. Hayward, Lundbeck Research USA
- Ken Lewis, OpAns
- Shane R. Needham, Alturas Analytics
|
| 3:00 pm - 4:15 pm |
Emerging Analytical Tools for Biologics (University II Ballroom)
Discussion Leader: Gabriella Szekely-Klepser, Assay Designs, Inc.
Challenges to Safety Evaluation of Small Molecule Pharmaceuticals and Biologics
Rakesh Dixit, Medimmune
Critical Factors in the Assessment of Immunogenicity of Therapeutic Protein
Michael Mullenix, Assay Designs, Inc.
Multiplexed Immunoassay Technologies for the Detection of Clinical Biomarkers
Fizal Nabbie, Bristol-Myers Squibb
|
| 4:15 pm - 4:45 pm |
Break/Roundtables |
| 4:45 pm - 6:00 pm |
"Nano" Applications to Small Molecule Analysis (University II Ballroom)
Held in conjunction with the North Jersey ACS Chromatography and Delaware Valley Drug Metabolism Discussion Groups
Discussion Leader: Nalini Sadagopan, Agilent Technologies
Mass Spectrometry Imaging of Small Molecules Using Nanofeature-Assisted Laser Desorption Ionization Mass Spectrometry
Lin He, North Carolina State University
Application of Chip-Based Nanoflow LC in Combination with Triple Quadrupole MS for PK Quantitation Studies
Stephan Buckenmaier, Agilent Technologies
Nano Applications to Small Molecule Analysis
Jack Henion, Advion BioSystems
|
| 6:00 pm - 8:00 pm |
Sponsor Hospitality – Evening Workshops (2nd Floor Boardroom Lobby Level)
Held in conjunction with the North Jersey ACS Chromatography & NMR Discussion Groups
- Applied Biosystems
- Eksigent
- McKinley Scientific
- Oxford Instruments
- Phenomenex
- Tandem Labs
|
| |
| Wednesday, October 29 |
7:30 am - 8:30 am |
Registration and Continental Breakfast (University Ballroom Foyer)
|
| 8:30 am - 10:00 am |
Biomarkers in Preclinical and Clinical Development (University II Ballroom)
Discussion Leader: Dawn Dufield, Pfizer
Urinary Stercobilin: A Potential Biomarker for Autistic Spectrum Disorders
Troy D. Wood, University of Buffalo
TBA
Nathan A. Yates, Merck Research Laboratories
Assaying Low Abundance Candidate Protein Biomarkers by Targeted Mass Spectrometry
Eric Kuhn, The Broad Institute
|
| 10:00 am – 10:30 am |
Break/Roundtables |
| 10:30 am – 12:15 pm |
Adding Another Dimension to the Quantitation of Peptides and Proteins (University II Ballroom)
Discussion Leader: Ray Bakhtiar, Merck Research Laboratories
Challenges on Determination of PEGylated-Peptide in Human Plasma Using LC-MS/MS to Support Clinical Studies
Yang Xu, Merck Research Laboratories
Can We Learn How To Make More Stable Peptides From in vitro Metabolism Studies?: Quantification and Characterization Approaches by LC-MS
Constantin Tamvakopoulos, Biomedical Research Foundation of the Academy of Athens
LC-MS/MS Approach for Quantification of Therapeutic Proteins in Plasma Using a Protein Internal Standard and 2D-Solid-Phase Extraction Cleanup
Ziping Yang, Novartis Pharmaceuticals
|
| 12:15 pm – 2:15 pm |
Exhibition Opens (University I Ballroom and Ballroom Foyer)
Poster Session/Roundtables (University I Ballroom)
Session Chairs: Michelle Dennehy, GlaxoSmithKline
James L. Stephenson, RTI International
Matthew E. Szapacs, GlaxoSmithKline
Tracie Williams, Centers for Disease Control & Prevention
Lunch & Learn Sessions and Poster Session (Villanova Amphitheater –
2nd Floor Boardroom Lobby Level)
High Performance Nanospray (Princeton I – 2nd Floor Boardroom Lobby Level)
- Gary A. Valaskovic, New Objective
- TBA
Tissue Analysis (Princeton II – 2nd Floor Boardroom Lobby Level)
- Stanley C. Murakami, Alta Analytical Laboratory
- Shane R. Needham, Alturas Analytics
|
| 2:15 pm – 3:30 pm |
Leveraging Analytical Chemistry for Drug Metabolism Studies (University II Ballroom)
Held in conjunction with the North Jersey ACS Chromatography and Delaware Valley Drug Metabolism Discussion Groups
Discussion Leader: Mingshe Zhu, Bristol-Myers Squibb
Industrialization of Metabolite Identification in Drug Discovery
Kevin Bateman, Merck Frosst Canada & Co.
Profiling Plasma Metabolites in First in Human Studies with High-Resolution LC/MS: A Challenging and Exciting Opportunity
Haiying Zhang, Bristol-Myers Squibb
|
| 3:30 pm – 5:30 pm |
Vendor Session (Villanova Amphitheater – 2nd Floor Boardroom Lobby Level)
Held in conjunction with the North Jersey ACS Mass Spectrometry Discussion Group and the Delaware Valley Drug Metabolism Discussion Group
Discussion Leader: Mark Hayward, Lundbeck Research USA
|
| 5:30 pm – 6:30 pm |
Exhibition & Social Hour (University I Ballroom and University Ballroom Foyer)
Held in conjunction with the North Jersey ACS Mass Spectrometry Discussion Group and the Delaware Valley Drug Metabolism Discussion Group
|
| 6:30 pm – 7:30 pm |
Dinner (University I Ballroom and University Ballroom Foyer)
Held in conjunction with the North Jersey ACS Mass Spectrometry Discussion Group and the Delaware Valley Drug Metabolism Discussion Group
|
| 7:30 pm – 7:45 pm |
ACS Announcements
CPSA – Distinguished Analytical Scientist Award Presentation
|
| 7:45 pm – 9:00 pm |
Keynote Lectures (University II Ballroom)
TBA
Thomas R. Covey, MDS Analytical Technologies
Protein and Peptide Analysis Using Microfabricated Fluidic Devices
J. Michael Ramsey, University of North Carolina
|
| |
| Thursday, October 30 |
| 7:30 am - 8:30 am |
Registration and Continental Breakfast (2nd Floor Boardroom Lobby Level)
|
| 8:30 am - 10:00 am |
Operational Excellence through IT and Hardware Solutions (Princeton I & II – 2nd Floor Boardroom Lobby Level)
Discussion Leader: Arkady Gusev, Pfizer
Improving Operation Efficiency of LC-MS Systems
Bernard Choi, Merck Research Labs
e-Lab Notebook Application to in ADME Studies: From ADME Data to ADME Knowledge
Dongyang He, Pfizer
An Integrated Turn-Key Solution for Large Scale Data Management
Randall Julian, Indigo BioSystems
|
| 10:00 am – 10:30 am |
Break/Roundtables
|
| 10:30 am – 12:15 pm |
Approaches to Overcome Poor Pharmacokinetic Properties for Lead
Compounds (Princeton I & II – 2nd Floor Boardroom Lobby Level)
Discussion Leader: Ayman El-Kattan, Pfizer
Prodrug Use in Overcoming Poor Plasma Exposure
Tycho Heimbach, Novartis Pharmaceuticals
Understanding and Overcoming Solubility Issues in Oral Absorption
Shobha Bhattachar, Eli Lilly and Company
|
| 12:15 pm – 2:00 pm |
Lunch/Roundtables – Is There Life Beyond LC/MS? (Princeton I & II – 2nd Floor Boardroom Lobby Level)
Discussion Leader: Richard C. King, Merck Research Laboratories
|
| 2:00 pm – 2:15 pm |
Wrap Up & Adjourn
Lucinda Cohen, Merck Research Laboratories |
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