Clinical & Pharmaceutical Solutions through Analysis
Where Technology and Solutions Meet

CPSA in Review

CPSA USA 2018Langhorne, PA

United to Beat Disease:
Partners in Healthcare, Partners in Science, Partners in Technology and Innovation

2018 Program Chair
Alla Kloss, Sanofi

Plenary Lecture
Florian Eichler, Harvard Medical School and Massachusetts General Hospital
Transformative Partnerships in Rare Neurological Diseases: the Case of Adrenoleukodystrophy

Distinguished Lecturer
Hui Zhang, Pfizer
The Next Generation HT BioAnalytical Platform for Drug Discovery: ADE-OPP-MS

Keynote Lecture
Kevin bateman, Merck
Smart Trials: Moving from Site-Centric to Patient-Centric Clinical Trials

Distinguished Analytical Scientist Award
Neil Spooner, Spooner Bioanalytical Solutions
Patient Centric Blood Sampling and Quantitative Bioanalysis A Personal Journey


CPSA USA 2017Langhorne, PA

Enabling Personalized Medicine: Connecting People, Disciplines and Technology

2017 Program Co-Chairs
Suzanne Cordovado, Centers for Disease Control
Emily Ehrenfeld, New Objective

Plenary Lecture
Kyriakie Sarafoglou, University of Minnesota
Screening, Diagnosis and Treatment of Newborns with Congenital Adrenal Hyperplasia: Opportunities for Improvements

Distinguished Lecturer
Timothy Garrett, University of Florida
Metabolomics: Discovery, Innovation, and Diagnostic Potential

Keynote Lecture
Carla Cuthbert, Center for Disease Control and Prevention
Bringing Precision Medicine to Public Health: The Role of Newborn Screening

Distinguished Analytical Scientist Award
Binodh DeSilva, Bristol-Myers Squibb
Dont Gamble with Bioanalysis in Enabling Precision Medicine: Bioanalysis Empowered by Innovation Shaped by Regulation


CPSA USA 2016Langhorne, PA

Analytical Chemistry at a Crossroad: Making Data Relevant to the Patient

2016 Program Co-Chairs
Timothy Garrett, University of Florida
Jim Shen, Bristol-Myers Squibb

Plenary Lecture
Scott Biller, Agios Pharmaceuticals
How Metabolic Biomarkers Drive Discoveries from the Bench to the Clinic

Distinguished Lecturer
Mark Cancilla, Merck
Understanding the Importance of Metabolic Stability for Developing New Chemical Modalities into Therapeutics

Keynote Lecture
Lorin Bachmann, Virginia Commonwealth University
Translation of Biomarker Assays into the Clinic What Differentiates Success from Failure?

Distinguished Analytical Scientist Award
Donald Chace, Pediatrix Analytical
Baselines and Bottom Lines Metabolism is Very Personal


CPSA USA 2015Langhorne, PA

Getting Medicines to Patients Faster by Eliminating the Bottlenecks in Drug Discovery and Development

2015 Program Co-Chairs
Chad Brisco, PRA Health Sciences
Naidong Weng, Janssen Pharmaceuticals

Plenary Lecture
David Evans, Janssen Reasearch and Development
Mechanism Based Drug Disposition Building Quality into Our Product Pipeline

Distinguished Lecturer
Douglas Lewis, US Drug Testing Labs, Inc
Fetal Alcohol Exposure - A 30 Year Search for a Reliable Biomarker

Keynote Lecture
Don Chace, Pediatrix Analytical
"Kicking it Up a Notch" with New Spices in Clinical Chemistry: Multiple Metabolite, Micro Sampling and LC/MS

Distinguished Analytical Scientist Award
Andy Hoofnagle, University of Washington
Pigs 'n Blankets: Mass Spectrometry and the Continuum of Human Health


CPSA USA 2014Langhorne, PA

Defining the Challenges of the Modern Analytical Laboratory:
The Risks and Reality of Personalized Healthcare

2014 Program Co-Chairs
Paul Corcoran, McKinley Scientific
Gary Valaskovic, New Objective

Plenary Lecture
Ann Weber, Merck
Adventures in Drug Discovery: Development of JANUVIA for Type 2 Diabetes

Distinguished Lecturer
Steven Wong, Wake forest University
Translational Mass Spectrometry Enabling Personalized Medicines

Keynote Lecture
Andy Hoofnagle, University of Washington
Helping the Clinical Lab Help Patients

Distinguished Analytical Scientist Award
Kevin Bateman, Merck
Bioanalysis, Smart PK/PD and the Future of Drug Development


CPSA USA 2013Langhorne, PA

Connecting Patients and Subject Numbers Through Analysis

2013 Program Chair
Shane Needham, Alturas Analytics

Plenary Lecture
Ola Saad, Genentech
Bioanalytical Strategy used for Ado-Trastuzumab Emtansine (T-DM1)

Plenary Lecture
Ellie Guardino, Genentech
Clinical Development of T-DM1

Distinguished Lecturer
Richard Kibbey, Yale University
Mitochondrial GTP Cycle: A Novel Metabolic Pathway Regulating Glucose Homeostasis

Keynote Lectures

Nathan Yates, University of Pittsburgh
How Cloud Computing Can Extend the Power and Versatility of Mass Spectrometry from the Bench to the Bedside

Fred McLafferty, Cornell University
An Analytical Scientist's Comments on A Distinguished One

Distinguished Analytical Scientist Award
Gary Valaskovic, New Objective, Inc.

CPSA USA 2012Langhorne, PA

Transforming Drug Discovery and Development Through Innovation: Past, Present and Future

2012 Program Chair
Joanna Pols, Merck

Plenary Lecture
Lisa A. Shipley, Vice President, Pharmacokinetics, Pharmacodynamics & Drug Metabolism at Merck
Navigating the Waters from Scientist to Administrator in an Ever-changing Environment: a 25-year Journey in the Pharmaceutical Industry

Keynote Lectures

Fred W. McLafferty, Cornell University
Mass Spectrometry:
Convenient Characterization of Complex Compounds with Colossal Content of Cool Comprehension

Neil L. Kelleher, Northwestern University
How to Keep Your Mass Spectrometer Alive:
A Manual of Step-by-Step Procedures for the Complete Idiot

Distinguished Analytical Scientist Award
Neil L. Kelleher, Northwestern University

CPSA USA 2011Langhorne, PA

Science and Technology Coming Together to Make a Difference

2011 Program Chair
Roger Hayes, Cetero Research

Plenary Lecture
Robert C. Murphy, University of Denver
Secrets in Lipid Biochemistry Revealed by Mass Spectrometry

Keynote Lectures

Ian Blair, University of Pennsylvania
Liquid Chromatography-Mass Spectrometry in Pharmacology Research and its Transition to Clinical Applications

Jack Henion, Advion BioSciences & Cornell University
A Scientific Adventure—LC/MS: From Academia to Entrepreneurship

Distinguished Analytical Scientist Award
Jack Henion, Advion BioSciences & Cornell University

Featured Symposia and Roundtables

  • Fast-to-Fail Paradigm - Lucinda Cohen, Merck; Tim Olah, Bristol-Myers Squibb
  • Microfluidics - Jack Henion, Advion; Gary Valaskovic, New Objective; Nathan Yates, Merck
  • Globalization of Bioanalytical - Mark Arnold, Bristol-Myers Squibb; Jerry Gromelski, QPS
  • Does LC/MS/MS Assay Have a Place in Biologics Development? - Guodong Chen, Bristol-Myers Squibb; Gabriella Szekely-Klepser, Allergan, Inc.
  • CRO-Innovator Interface - Chad Briscoe, PRA International; Ron Shoup, AIT Bioscience; Eric Woolf, Merck
  • New Technologies - Kevin Bateman, Merck and Rick King, PharmaCadence
  • Clinical Diagnostics: From Biology to Analytical Chemistry - Kenneth Lewis, OpAns

CPSA USA 2010Langhorne, PA

From Data to Biology: Analytical Measurements to Drive Pharmaceutical R&D

2010 Program Chair
Petia Shipkova, Bristol-Myers Squibb

Plenary Lecture
Bradley L. Ackermann, Eli Lilly and Company
Using Quantitative Mass Spectrometry to Enable Clinical Translation Through Analysis of Biochemical Markers

Keynote Lectures
Jonathan Josephs, Bristol-Myers Squibb
Accuracy for the Masses: Resolution of the Quan/Qual Debate

Mark Sanders, Thermo Fisher Scientific
Resolution for the Masses: The Debate is Over Now What?

Distinguished Analytical Scientist Award
Mark Sanders, Thermo Fisher Scientific

Featured Symposia and Roundtables

  • Biomarker/Toxicology Marker Discovery - Mike Reily, Bristol-Myers Squibb
  • DMPK with Accurate Mass - Jonathan Josephs, Bristol-Myers Squibb
  • Dried Blood Spots - Chris Evans, GlaxoSmithKline
  • Biologics as Pharmaceutical Agents - Yan-Hui Liu, Merck; Ragu Ramanathan, BMS
  • Imaging - Dieter Drexler, Bristol-Myers Squibb
  • ADME - Dan Morgan, Bristol-Myers Squibb
  • Proteins and Peptides as Biomarkers - Sue Abbatiello, Broad Institute
  • Bioinformatics and Biostatistics - Jim Stephenson, RTI International
  • Where Do We Go From Here? - Kevin Bateman, Merck and Rick King, PharmaCadence

CPSA USA 2009Langhorne, PA

Impacting Biology through Analysis

2009 Program Chair
Kevin P. Bateman, Merck Frosst Canada

Plenary Lecture
Ian Jardine, Thermo Fisher Scientific
The Impact of High-Performance Mass Spectrometry on Biology Research

Keynote Lectures
Walter A. Korfmacher, Schering-Plough Research Institute
Using Mass Spectrometry in Drug Discovery: Past, Present and Future

Thomas A. Baillie, University of Washington
The Impact of Mass Spectrometry in Pharmaceutical Lead Optimization:
Studies on Metabolic Activation

Distinguished Analytical Scientist Award
Walter A. Korfmacher, Schering-Plough Research Institute

Featured Symposia and Roundtables

  • High Performance Workflows: Emerging Applications for Simultaneous Qualitative-Quantitative Analysis
  • Why Biomarkers for Toxicology and Clinical Diagnostics Fail or Don't Have Broader Acceptance?
  • Small Interfering RNA and Gene Silencing: Emerging Opportunities for Analysis in Drug Discovery and the Potential of a Bioanalytical Equivalent
  • Small Molecule Biomarker Assay Development and Validation
  • Protein Based Biomarkers
  • Tools for Understanding Biology Through Analysis
  • Toxicity Markers
  • Peptide and Protein Quantitation: Are Trypsin and MRM Sufficient?
  • High Throughput Quantitation: Going Faster by Going Faster and Going Slower
  • Maintaining Our Innovative Fitness During Times of Transition

CPSA USA 2008Langhorne, PA

The Value Proposition of Analytical Chemistry

2008 Program Chair
Lucinda Cohen, Merck Research Laboratories

Plenary Lecture
David M. Hercules, Vanderbilt University
Mass Spectrometry of Synthetic Polymers: Some Challenges and Some Successes

Keynote Lectures
Thomas R. Covey, MDS Analytical Technologies
Where Can We Go From Here? An Assessment of the Limits to Sensitivity of Electrospray and MALDI

J. Michael Ramsey, University of North Carolina
Protein and Peptide Analysis Using Microfabricated Fluidic Devices

Distinguished Analytical Scientist Award
Thomas R. Covey, MDS Analytical Technologies

Featured Symposia and Roundtables

  • Excellence in Bioanalysis Through Automation
  • Insourcing, Outsourcing and Offshoring
  • Emerging Analytical Tools for Biologics
  • "Nano" Applications to Small Molecule Analysis
  • Biomarkers in Preclinical and Clinical Development
  • Adding Another Dimension to the Quantitation of Peptides and Proteins
  • Leveraging Analytical Chemistry for Drug Metabolism Studies
  • Operational Excellence through IT and Hardware Solutions
  • Approaches to Overcome Poor Pharmacokinetic Properties for Lead Compounds
  • Is There Life Beyond LC/MS?

CPSA USA 2007 Langhorne, PA

2007 Program Chair
Nalini Sadagopan, Pfizer

Plenary Lecture
Jonathan L. Josephs, Bristol-Myers Squibb
Why Cant We All Just Get Along: An Integrated Approach to Solving ADME Issues

Keynote Lectures
Bradley L. Ackermann, Eli Lilly and Company
From Bioanalytical to Biomarkers - Using Quantitative Mass Spectrometry to Address Biological Bottlenecks

Liang Li, University of Alberta
Development and Applications of Improved Sample Handling and LC-MS Techniques for Comprehensive Proteome and Metabolome Analysis

Distinguished Analytical Scientist Award
Bradley L. Ackermann, Eli Lilly and Company

Featured Symposia and Roundtables

  • Biomarkers in Preclinical Development
  • Bioanalytical CRO Assay Transfers
  • Proteo-Metabonomic Strategies in Drug Development
  • High Throughput Approaches Fast Separations
  • Biologics
  • Metabolomics and Metabonomics
  • Omics Technologies
  • New Technologies and Trends in Bioanalysis
  • Drug Metabolism in Preclinical and Clinical Development
  • Driving Pharmaceutical Quality
  • Biomarkers in Clinical Development
  • ADME Strategies: Past, Present and Future

CPSA USA 2006 Princeton, NJ

2006 Program Chair
Jing-Tao Wu, Millennium Pharmaceuticals

Plenary Lecture
Mark L. Powell, Bristol-Myers Squibb
Analytical Chemistry: A Changing Paradigm of Advanced Process Models, Tools and Technologies in R&D

Keynote Lectures
Richard C. King, Merck Research Laboratories
Ion Formation from Complex Solutions: Understanding Matrix Effects and Ionization Suppression

David M. Lubman, University of Michigan
Markers of Cancer Using a Liquid Proteomics Approach

Distinguished Analytical Scientist Award
Richard C. King, Merck Research Laboratories

Featured Symposia and Roundtables

  • Proteins and Early Biology
  • Discovery Strategy: The Minimalist Approach Versus the Fail Faster Model
  • Predictive Toxicology
  • Measurement of Drug in Clinical Development
  • Pharmaceutical Sciences - Analytical New Strategies
  • Chemistry in Drug Discovery
  • The Unsolved Mystery: Reactive Metabolites
  • AAPS/FDA Bioanalytical Workshop: Take Home Messages and Implementation
  • Clinical Development Measurement of Drug Effects
  • Biomarkers in Drug Discovery
  • Pharmaceutical Sciences - Analytical New Technologies
  • Emerging New Technologies
  • Pharmacokinetics & Pharmacodynamics

CPSA USA 2005 Princeton, NJ

2005 Program Chair
Bradley L. Ackermann, Eli Lilly and Company

Plenary Lecture
R. Graham Cooks, Purdue University
Enabling Biology Through Analytical Innovation: Tissue Imaging in the Ambient Environment Using DESI Mass Spectrometry

Keynote Lectures
Yining Zhao, Pfizer
Modern Separation Science: Quo Vadis? The Pursuit of Higher Resolution and Higher Speed Separation in Drug Discovery and Development

John T. Stults, Predicant Biosciences
Discovery and Clinical Validation of Serum Biomarkers for Disease Diagnosis

Strong>Distinguished Analytical Scientist Award
Mark J. Cole, Pfizer

Featured Symposia and Roundtables

  • Biomarkers: Proteomics Strategies
  • Metabolite Identification: Emerging Strategies to Make Better Use of Time & Resources
  • Chromatography
  • Bioanalytical: Current Strategies
  • Pharmaceutical Properties: Compound Library Analysis & Profiling
  • Biomarkers: Metabonomics Strategies
  • Bioanalytical: Driving Technologies & Methodologies
  • Pharmaceutical Properties: HT ADME
  • Biomarkers: New Technologies & Approaches
  • NMR Analysis: Emerging Analysis Strategies & Methodologies
  • Bioanalytical: Exploratory Technologies

CPSA USA 2004 Princeton, NJ

2004 Program Chairs
Steven A. Hofstadler, Ibis Therapeutics
Mark Sanders, Bristol-Myers Squibb

Plenary Lecture
Richard D. Smith, Pacific Northwest National Laboratory
Quantitative and Ultra-Sensitive High Throughput Proteomics

Keynote Lectures
David H. Russell, Texas A&M University
Molecular Imaging Using MALDI and Ion Mobility-Mass Spectrometry: A New Paradigm for Proteomics

Richard Beger, Food & Drug Administration
Metabolic Profiles of Drug Toxicity and Disease

Featured Symposia and Roundtables

  • Biomarkers: Initiatives, Perspectives & Approaches
  • How Do We Set Priorities in Drug Discovery & Development?
  • Outsourcing Trends: Emerging Business Models & Overseas Partners
  • High Throughput Analysis & Information Management Strategies
  • Current Strategies & Preferences for Metabolite Identification
  • Biomarker Discovery
  • High Throughput ADME & Pharmaceutical Property Profiling
  • Tissue Imaging: Localization of Drugs & Metabolites
  • Biomarker Evaluation
  • Emerging Technologies & Applications

CPSA USA 2003 Princeton, NJ

2003 Program Chair
Nigel J. Clarke, ActivX Biosciences

Plenary Lecture
Simon J. Gaskell, The University of Manchester Institute of Science and Technology
The Multi-Dimensionality of the Proteome

Featured Symposia and Roundtables

  • Functional Proteomics: Quantitation
  • Discovery and Validation of Proteomic Biomarkers for Drug Development
  • Functional Proteomics: Relationships
  • Bioinformatics for Proteomics
  • Lead Optimization
  • Reactive Xenobiotic Intermediates
  • Compound Library Analysis and Profiling
  • Conversion of Data to Information: Dissemination of Information to Drive Therapeutic Area Projects
  • Recent Regulatory Guidance: Bioanalytical Impact on Drug Development
  • Bioanalytical LC/MS/MS Methods: Perspectives and Lessons Learned
  • Research Informatics in Drug Development

CPSA USA 2002 Princeton, NJ

2002 Program Chair
Kenneth L. Morand, Procter & Gamble Pharmaceuticals

Plenary Lecture
Joseph A. DiMasi, Tufts Center for the Study of Drug Development
Trends in the Economics of Pharmaceutical Innovation: Cost, Time, and Risk

Featured Symposia and Roundtables

  • Genomics/Post-Genomics Trends
  • Instrumentation for Protein Characterization: Emerging Trends in Proteomic Analysis
  • Metabonomics
  • Advances in Microfluidics Technology
  • The Value of the Corporate Compound Collection: Protecting Your Investment
  • Preclinical Lead Optimization: Are We Making A Difference?
  • Emerging Technologies for Drug Discovery & Development
  • Data Management in a High-Throughput Analysis Environment
  • Why Does Method Development Take So Long?
  • In-Source, Out-Source: What Do Pharmaceutical Companies Do for Bioanalytical Support?
  • Crystal City Guideline Review

CPSA USA 2001 Princeton, NJ

2001 Program Chair
Robyn A. Rourick, DuPont Pharmaceuticals

Plenary Lecture
Donald G. Robertson, Pfizer
Of Mice and Magnets: Metabonomic Technology as a Tool for Rapid- Throughput Toxicity Evaluation

Featured Symposia and Roundtables

    Structure Profiling
  • Sample Preparation & Chromatography
  • High Throughput Synthesis Support: Open-Access Applications and Formats
  • The Emerging Future/Role of Proteomics in Drug Discovery
  • Pharmaceutical Property Profiling: Metrics and Implementation
  • Mass Spectrometry & Data Management
  • Hyphenated NMR Methods in Pharmaceutical R&D
  • Strategies for Overcoming the Bottlenecks in Assessing Toxicity
  • Predictive Models for Drug Discovery Screening
  • Technology Transfer: Drug Discovery to Drug Development Perspectives
  • Emerging Technologies

CPSA USA 2000 Princeton, NJ

2000 Program Chair
Todd A. Gillespie, Eli Lilly and Company

Plenary Lecture
John R. Yates, The Scripps Research Institute
Proteomics Using Multidimensional Chromatography and Tandem Mass Spectrometry

Featured Symposia and Roundtables

  • New Technologies and Approaches for Drug Metabolism
  • Sample Preparation
  • Chromatography
  • Structure and Purity Determination: How Much and When?
  • How to Demo/Purchase an LC/MS Instrument: Experiences and Perspectives
  • Drug Discovery in the Post-Genome Era: Proteomcs/Genomics
  • Predictive Models for Lead Optimization and Selection
  • Mass Spectrometry
  • Data Management
  • Mass Spectrometry in the QC Laboratory: Are We Ready?
  • Purification Systems for Combinatorial Chemistry
  • Is LC/TOF a Viable Bioanalytical Tool?
  • Data Management and Manipulation
  • Drugability High Throughput Screening
  • In Vitro Methods
  • New Technologies and Future Trends for High Throughput

CPSA 1999 Princeton, NJ

1999 Program Chair
Mike S. Lee, Milestone Development Services

Plenary Lecture
Richard M. Caprioli, Vanderbilt University
Mass Spectrometry Imaging: A Tool for the 21st Century

Featured Symposia and Roundtables

  • Proteomics
  • Sample Preparation
  • Combinatorial Chemistry
  • Automation
  • Fast Chromatography
  • Lead Optimization
  • Accelerated Drug Discovery
  • Using Dedicated Instruments
  • Well Characterized Biologics
  • Information Management
  • Lead Identification
  • Emerging Technologies

CPSA 1998 Princeton, NJ

1998 Program Chairs
Mike S. Lee, Milestone Development Services
Edward H. Kerns, Milestone Development Services

Plenary Lecture
Richard A. Yost, University of Florida
Pushing the Bioanalytical Envelope with Ion Trap Mass Spectrometry

Featured Symposia and Roundtables

  • Metabolism
  • Analysis Strategies
  • Emerging Technologies
  • Biomolecular Separations
  • Automation
  • Combinatorial Chemistry
  • Impurities, Degradants and Natural Products
  • Recruiting, Developing and Motivating Scientists
  • Outsourcing
  • Biomolecule Analysis
  • Pharmacokinetics

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