Training
Introductory courses are modularly designed to
provide customization of material for specific
needs. The purpose is to assist scientists and
managers build foundational knowledge and practical
skills leading to the generation of reliable
information for research, development, and
manufacturing.
Featured Courses
Introduction to Mass Spectrometry This
introductory course provides a comprehensive
overview of the components of a mass spectrometer
system as well as the fundamental processes involved
in producing mass spectral information. The
different varieties of MS interfaces and mass
analyzers are described. Easy to understand industry
applications are discussed. No prior mass
spectrometry experience is required.
Introduction to Mass Spectrometry This
course provides an understanding of the key
components of LC/MS instrumentation, operation,
advantageous features, and the information derived
from analysis. The conversion of LC/UV methods to
LC/MS is discussed. Performance characteristics of
mass analyzers and LC/MS interfaces are described.
Industry related applications of LC/MS are
highlighted.
Qualitative LC/MS This course outlines
LC/MS approaches for structure identification. An
overview of instrumentation, strategies, and methods
currently used in the industry is presented.
Practical advantages of MS/MS are highlighted with
straight-forward tips for spectral interpretation.
LC/MS/MS applications for the structure analysis of
metabolites, impurities, natural products, and
biomolecules are reviewed. The role of structure
databases for technology transfer and product
support is illustrated.
Quantitative LC/MS The advantages of LC/MS
techniques for quantitative analysis are presented
in this course. The steps involved with developing a
LC/MS quantitative method are illustrated along with
the practical uses of selected ion monitoring and
selected reaction monitoring analyses. The utility
of internal standards and standard curves for
analysis are emphasized. Examples of LC/MS/MS
methods for rapid metabolic stability assessment,
cell uptake and clinical pharmacokinetics are
described.
Analytical Opportunities in the Pharmaceutical
Industry A recent shift in focus within drug
development toward the early and quick evaluation of
drug candidates has resulted in significant change
throughout the pharmaceutical industry. New
strategies have emerged, which emphasize fast
analysis times, high throughput capabilities and
rugged, reliable analytical methods. With the
increased utilization of combinatorial drug
discovery technologies, organizations are realizing
that previously established metrics for resource
utilization cannot be simply scaled-up
proportionately. Creative strategies must be devised
as part of an overall process and successfully
implemented. This course will provide an
overview of the evolving drug development process
from an analytical perspective, and provide insights
into the critical role of analytical technology and
measurement for accelerated development. Recent
examples that illustrate the changing needs of the
pharmaceutical researcher will be described. The
emergence of new criteria for method development,
automated analysis, data handling, and information
management will be discussed. "Analytical
opportunities" will be addressed with regard to
significant changes in strategies for pharmaceutical
analysis.
Collaborative Course
High Throughput Method Development and Automation
Approaches for Bioanalytical Sample Preparation
Offered in Collaboration with Sample Prep Solutions
This practical one-half day course presents high
throughput techniques for performing bioanalytical
sample preparation prior to LC/MS/MS analysis.
Applications of the 96-well microplate format as a
solution to meeting the increasing demands for
greater throughput in bioanalysis are reviewed.
Specific approaches to performing rapid and
efficient method development utilizing the
microplate format are emphasized. The sample prep
procedures covered include solid-phase extraction,
protein precipitation, liquid/liquid extraction and
filtration. Procedures demonstrating the use of
semi-automated liquid handling workstations (e.g.,
MultiPROBEII and Quadra96) with the microplate
format are also presented.
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